Rabbit Anti-CK12 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:CK12
IR:Immunogen Range:151-250/494
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3859
Swiss Prot:Q99456
Source:KLH conjugated synthetic peptide derived from human CK12/Cytokeratin 12:151-250/494
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Cytokeratin 12 is a member of the intermediate filament family of proteins and is a heterotetramer of two type I and two type II keratins. Keratin 3 is specifically expressed in the corneal epithelium with family member KRT12. Cytokeratin 12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Defects in KRT3 and KRT12 are a cause of Meesmann corneal dystrophy (MCD), an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Symptoms occur in adulthood and include rupture of the corneal microcysts that may lead to photophobia, contact lens intolerance and intermittent diminution of visual acuity. Defects in KRT12 are a cause of juvenile epithelial corneal dystrophy of Meesmann (MCD)
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Rabbit
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： CK12;65 kDa cytokeratin;CK 12;CK 3;CK12;CK3;Cytokeratin 12;K1C12_HUMAN;
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