Rabbit Anti-ATP6V0A1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:ATP6V0A1
IR:Immunogen Range:41-140/837
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:535
Swiss Prot:Q93050
Source:KLH conjugated synthetic peptide derived from human V-ATPase A1:41-140/837
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The subunit of the vacuolar proton pump is a V-ATPase that has two different isoforms. The type I isoform contains an 18-base pair insert and is expressed in brain, whereas the truncated type II isoform is more widely expressed, including lung, kidney and spleen. The subunit of the vacuolar proton pump is located in clathrin-coated vesicles and is also found in osteoclasts. It consists of two fundamental domains, a hydrophilic amino-terminus, which has greater than 30% charged residues, and a hydrophobic carboxy terminus, which contains at least six transmembrane regions. The proton pump functions in coupling ATP hydrolysis by the cytoplasmic subunits to proton translocation by the intramembranous components of the pump. The inactivation of the osteoclast-specific vacuolar proton ATPase subunit is responsible for the lack of the enzyme in the apical membranes of osteoclast cells in osteosclerotic mutant mice, thus preventing the resorption function of these cells and leading to the osteopetrotic phenotype. The subunit, which co-localizes with the late endosomal marker Rab7 on vacuolar membranes, is essential for vacuole formation by selective swelling of late endosomes.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Rabbit
Sheep
![image.png image.png](/SupplyImg/2023-08-02/6382657131003853165579614.jpg)
仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: ATP6V0A1;V ATPase;V ATPase A;V ATPase A1;V-type proton ATPase;V-ATPase 95 kDa isof; AltName: Full=Vacuo;VPP1_HUMAN;
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