Rabbit Anti-phospho-SP1 (Thr453) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-SP1 (Thr453)
IR:Immunogen Range:IR(p-T)PT
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:6667
Swiss Prot:P08047
Source:KLH conjugated synthesised phosphopeptide derived from human SP1 around the phosphorylation site of Thr453:IR(p-T)PT
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Sp1 is a sequence-specific transcription factor that recognizes GGGGCGGGGC and closely related sequences, which are often referred to as GC boxes. Sp1 was initially identified as a HeLa cell-derived factor that selectively activates in vitro transcription from the SV40 promoter and binds to the multiple GC boxes in the 21-bp repeated elements in SV40. The sequence specificity of DNA binding is conferred by Zn (II) fingers, whereas a different region of Sp1 appears to regulate the affinity of DNA binding. Sp1 belongs to a subgroup of transcription factors that are phosphorylated upon binding to promoter sequences. Evidence suggests that the early growth response gene, Erg-1 (also known as Zif268 or NGF1-A) (7), may downregulate certain mammalian gene promoters by competing with Sp1 for binding to an overlapping binding motif. The gene encoding human Sp1 maps to chromosome 12q13.1.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： phospho-SP1 (Thr453);SP1 (phospho T453);p-SP1 (phospho T453;SP1 (phospho-Thr453);SP1 (phospho-T453);TSFP1;Specificity protein ;SP1_HUMAN;
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