Rabbit Anti-c-Jun Monoclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:c-Jun
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:3725
Swiss Prot:P05412
Source:Recombinant human c-Jun protein (1-100aa):
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-1000)
Cross Reactive Species:Human
Mouse
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： c-Jun;Transcription factor;JUN;AP1;nhancer Binding Prot;p39;JUNC;JUN_HUMAN;
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