Rabbit Anti-PKN1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:PKN1
IR:Immunogen Range:201-300/942
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:5585
Swiss Prot:Q16512
Source:KLH conjugated synthetic peptide derived from human PKN1:201-300/942
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Size:50ul
Concentration:1mg/ml
Applications:IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Cow
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： PKN1;DBK; PAK-1;PKC1; PKN ALPHA;PKN;Pkn1;PKN1_HUMAN;
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