Rabbit Anti-Neutrophil Elastase Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Neutrophil Elastase
IR:Immunogen Range:51-150/265
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:1991
Swiss Prot:P08246
Source:KLH conjugated synthetic peptide derived from human Neutrophil Elastase:51-150/265
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009].
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Mouse
Rat
仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: Neutrophil Elastase;ELA2;ELANE;Elastase 2;Elastase 2 neutrophi;HLE;PMN Elastase;ELNE_HUMAN;
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