Mouse Anti-CD45 Monoclonal Antibody
DATASHEET
Host:Mouse
Target Protein:CD45
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG1
Entrez Gene:5788
Swiss Prot:P08575
Source:Recombinant human CD45:
Purification:affinity purified by Protein G
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008].
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-1000)
ELISA(1:1000-5000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1:50)
Cross Reactive Species:Human
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仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： CD45;B220;cd45 antigen;ec3.1.3.48;CD45R;GP180;PTPRC;PTPRC_HUMAN;
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