Rabbit Anti-Cyclin D1 Monoclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Cyclin D1
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:595
Swiss Prot:P25322
Source:KLH conjugated synthetic peptide derived from human Cyclin D1 around C-terminal:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008].
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
IHC-P(1:50-200)
IHC-F(1:50-200)
ICC(1:50-200)
IF(1:50-200)
Cross Reactive Species:Human
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"仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： Cyclin D1;CyclinD1;B-cell leukemia 1;BCL1 oncogene;CCND1 protein; CCND1/FSTL3 fusion ;CCND1/IGHG;CCND1_HUMAN;
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