Rabbit Anti-NOBOX Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:NOBOX
IR:Immunogen Range:
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:18291
Swiss Prot:Q8VIH1
Source:KLH conjugated synthetic peptide derived from mouse NOBOX:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Early ovarian folliculogenesis is characterized by the breakdown of germ cell clusters and formation of primordial follicles. The cessation of ovarian function under the age of 40 years results in premature ovarian failure (POF) and is accompanied by amenorrhea, hypoestrogenism and elevated serum gonadotropin concentrations. 1% of all women are affected by POF, and mutations in a few genes, including inhibin? fsh receptor and the LH/choriogonadotropin receptor have been linked to POF. In addition, several germ cell specific genes and downstream transcription factors are thought to play and important role in human oogenesis. NOBOX (newborn ovary homeobox gene), an ooctye-specific homeobox gene, is a critical protein involved in early folliculogenesis. Missense mutations have been shown to cause nonsyndromic ovarian failure by disrupting the NOBOX proteins ability to bind to NOBOX DNA-binding element (NBE), and thereby inhibiting its regulation of Pou5f1 and GDF-9. NOBOX expression in the ovary is oocyte specific, but it shows expression in adult testis and pancreas as well.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:400-800)
Cross Reactive Species:Mouse
Rat
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： NOBOX;Homeobox ;NOBOX;Nobox;NOBOX Oogenesis ;OG2;Og2x;NOBOX_HUMAN;
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