AMG-3969是有效的葡萄糖激酶-葡糖激酶调节蛋白(GK-GKRP)相互作用的干扰物,IC50值为4 nM。AMG-3969 exhibits potent cellular activity with an EC50 of 0.202 μM and IC50 of 4 nM, It potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation in vitro (isolated hepatocytes)
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