别名
R(+)-Butylindazone,R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid
溶解性
H2O: insoluble <0.11 mg/mLDMSO: >20 mg/mL0.1 M HCl: insoluble0.1 M NaOH: solubleethanol: soluble
应用
R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:short circuit current (Isc) in rat semicircular canal duct (SCCD) epitheliumuptake of grepafloxacin by THP-1 monocytesthe uptake of moxifloxacin by THP-1 monocytes
生化/生理作用
[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl−) co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
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