一般描述
Sphinganine-1-Phosphate is a phosphorylated derivative of C20 base sphinganine.
生化/生理作用
Exogenous sphinganine-1-phosphate activates sphingosine-1-phosphate receptor 1 (S1P1). It exhibits protective effects against hepatic and renal ischemia and reperfusion (IR). Sphingosine-1 phosphate and sphinganine-1-phosphate are bioactive lipid mediators. Sphinganine-1-phosphate acts opposite to sphingosine-1 phosphate activities. Increased concentration of sphinganine-1-phosphate acts as a potential biomarker for fumonisin exposure and toxicity in mice.
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
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