| 产品编号 | 371970 |
| 品牌 | Sigma |
| 警告 | Toxicity: Harmful (C) |
| 运输 | ambient |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 颜色 | white |
| 分子量 | 364.29 |
| 溶解性 | water: 1?mg/mL |
| 质量水平 | 100 |
| 储存条件 | OK to freeze |
| 储存温度 | 2-8°C |
别名
HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem,Fasudil, (5-Isoquinolinesulfonyl)homopiperazine, 2HCl, PKG Inhibitor VII
一般描述
A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 μM), protein kinase G (Ki = 1.6 μM), and myosin light chain kinase (Ki = 3.6 μM). Also reported to potently inhibit Rho-associated kinase (ROCK; IC50 = 10.7 μM). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 μM), protein kinase G (Ki = 1.6 μM), and myosin light chain kinase (Ki = 36 μM). Also reported to potently inhibit Rho-associated kinase (ROCK; IC50 = 10.7 μM). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
生化/生理作用
Cell permeable: yes
Primary Target
PKA
Product competes with ATP.
Reversible: yes
Target IC50: 10.7 μM inhibiting Rho-associated kinase (ROCK)
Target Ki: .6 μM, 1.6 μM, 36 μM, inhibiting protein kinase A, protein kinase G, myosin light chain kinase, respectively
重悬
Following reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
其他说明
Watanabe, K., et al. 2007. Nature Biotech.25, 681.
Sw?rd, K., et al. 2000. J. Physiol.522, 33.
Takizawa, S., et al. 1993. Eur. J. Pharmacol. 250, 431.
Seto, M., et al. 1991. Eur. J. Pharmacol.195, 267.
Shirotani, M., et al. 1991. J. Pharmacol. Exp. Ther.259, 738.
Asano, T., et al. 1990. Eur. J. Pharmacol.190, 365.
Sasaki, Y., and Sasaki, Y. 1990. Biochem. Biophys. Res. Commun.171, 1182.
Asano, T., et al. 1989. Br. J. Pharmacol. 98,1091.
关键字： HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem;HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem价格;HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem厂家;103745-39-7;Sigma
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