中文名:二硫化四乙基秋兰姆
英文名:Tetraethylthiuram disulfide
中文别名:双硫伦
英文别名:TETD|Disulfiram|Contrapot|Ethyl tuads|Tetraethylthiuram disulfide|CHEBI:4659|Ethyl Thiudad|Hoca|NSC 190940|Contralin|Tetraethylthiuram sulfide|Antiaethan|Disulfuram|Antabuse (TN)|Antalcol|diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate|Dupon 4472
纯度:97%
货号:T110101
包装:25g、100g、500g
Cas号:97-77-8
产品介绍:
Disulfiram is a DNA demethylating agent and DIG1 inducer which inhibits prostate cancer cell growth by inhibition of DNA methyltransferase (Dnmt). In addition, studies indicate that disulfiram inhibits aldehyde dehydrogenase (ALDH) resulting in the accumulation of acetaldehyde upon ethanol ingestion. Alternate studies show that disulfiram also inhibits dopamine β-hydroxylase (DBH), an enzyme important in converting dopamine to norepinephrine in noradrenergic neurons. Futhermore, disulfiram can reduce toxicity and carcinogenesis by inhibiting the cytochrome P450IIE1 (CYP2E1). It has been reported that disulfiram can also inhibit tumor cell growth via binding to cellular copper, which inhibits proteosome activity and induces apoptosis. Disulfiram is an inhibitor of ADH and V-ATPase醇脱氢酶抑制剂。 An ALDH and tumor cell growth inhibitor
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