中文名:乙氧基试卤灵
英文名:Resorufin ethyl ether
中文别名:7-乙氧基resorufin
英文别名:7-ER|7-Ethoxy-3H-phenoxazin-3-one|SCHEMBL104497|FT-0668125|UNII-59AF853SW7|BDBM21360|J-100239|59AF853SW7|HY-D0145|AS-59402|CHEBI:34480|RESORUFINETHYLETHER|Q27116097|Resorufinethyl ether|7-Ethoxyresorufin|3H-Phenoxazin-3-one, 7-ethoxy-|7-Ethoxyphenoxazone|
纯度:≥95% (UV)
货号:R131523
包装:25mg、5mg、1mg
Cas号:5725-91-7
存储温度:-20°C储存
产品介绍:
7-Ethoxyresorufin is a fluorimetric substrate and suicide inhibitor of CYP (cytochrome P450). Also shown to inhibit several reductase enzymes, specifically CYPOR (NADPH-P450 reductase). The binding to CYP (cytochrome P450) is thoμght to inhibit the vasorelaxant response to acetylcholine. 7-Ethoxyresorufin has also demonstrated inhibition of NO synthesis by uncoupling neuronal NOS1 (nitric oxide synthase); it is a noncompetitive inhibitor of neuronal NOS1 with respect to L-arginine with a Ki value of 0.76 +/- 0.06 μM. 7-Ethoxyresorufin is a substate of CYP1A1.7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.
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