中文名:鹅去氧胆酸
英文名:Chenodeoxycholic acid
中文别名:鹅脱氧胆酸
英文别名:chenodeoxycholic acid|Chenodiol|474-25-9|Chenix|Chenic acid|Cdca|Chenodesoxycholic acid|Chenodeoxycholate|Gallodesoxycholic acid|Chendol|Anthropodeoxycholic acid|Anthropodesoxycholic acid|Anthropododesoxycholic acid|Chenofalk|Chenodesoxycholsaeure|Chenoco
纯度:98%
货号:C104902
包装:100g、25g、5g
Cas号:474-25-9
存储温度:2-8°C储存,避光
产品介绍:
Chenodeoxycholic Acid, Free Acid and its 7β-isomer ursodeoxycholic acid are potent (nanomolar affinity) selective inhibitors of DD2 (AKR1C2). These compounds were non-competitive inhibitors of AKR1D1 yielding Ki values of 3.2 μM for chenodeoxycholic acid. This chemical is a hydrophobic primary bile acid, which increases intracellular Ca2+ in rat hepatocyte couplets. Studies indicate that Chenodeoxycholic Acid induces apoptosis throμgh a PKC dependent pathway. It is known that Chenodeoxycholic Acid is essential in the metabolism of cholesterol via activation of nuclear receptors. This bile acid can also bind to BABP with a stoichiometery of 1:2. Alternate studies indicate that chenodeoxycholic acid can inhibit the expression of IL-6 and cell viability in QBC939 cells.An apoptosis inducer via PKC-dependent signalling pathway.
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