中文名:SU 16f,PDGFRβ抑制剂
英文名:SU 16f
中文别名:5-[1,2-二氢-2-氧代-6-苯基-3H-吲哚-3-亚甲基)甲基] -2,4-二甲基-1H-吡咯-3-丙酸
纯度:≥98%(HPLC)
货号:S288019
包装:10mg、50mg、100mg
Cas号:251356-45-3
存储温度:避光,-20°C储存
产品介绍:
产品介绍:A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC50 = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC50 = 0.14, 2.29, and >100 µM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC50 = 0.11 and 21.9 µM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC50 = 10 µM).
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