中文名:LIT-927
英文名:LIT-927
英文别名:LIT-927|2172879-52-4|4-(4-Chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)pyrimidin-2(1H)-one|LIT927|CHEMBL4166454|6-(4-chlorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-1H-pyrimidin-2-one|SCHEMBL19782686|GTPL10075|LIT 927|DTXSID001162146|LIT 927; LIT927|BCP29866|EX
纯度:99%
货号:L414198
包装:25mg、5mg、100mg
Cas号:2172879-52-4
存储温度:-20°C储存
产品介绍:
Information
LIT-927 is a novel neutraligand ofCXCL12with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma.
Targets
CXCR4 ; CXCL12 ; 267 nM(Ki)
In vitro
LIT-927 is able to bind selectively CXCL12 and to inhibit CXCL12-CXCR4 interaction.
In vivo
In a murine model of hypereosinophilia, LIT-927 shows a large and statistically reliable inhibition of eosinophil recruitment. It inhibits allergic eosinophilic airway inflammation in mice when administered orally or locally.
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