中文名：双醋炔诺醇
英文名：Ethynodiol diacetate
英文别名：8080 CB;19-Norpregn-4-en-20-yne-3,17-diol, 3,17-diacetate, (3β,17α)-
纯度：10mM in DMSO
货号：E408955
包装：1ml
Cas号：297-76-7
存储温度：-80℃储存
产品介绍：
Information
Ethynodiol diacetate (8080 CB) is one of the first synthetic progestogens used in contraceptive pills.
In vitro
Nordihydroguaiaretic acid (NDGA) (< 1.5 μM) decreases the percentage of sister chronnatid exchanges (SCEs) in human lymphocyte culture treated with ethynodiol diacetate (150 μg/mL). Since the NDGA treatment, in the presence of S9 mix, reduce the genotoxic damage by ethynodiol diacetate, the reduction may be due to the inhibition of cytochrome P450s which prevents the metabolic activation of ethynodiol diacetate or NDGA may act as a free radical scavenger. Ethynodiol diacetate (150 μg/mL) increases sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) frequencies and inhibits lymphocyte proliferation in the presence of S9 mix in human lymphocyte.
In vivo
Ethynodiol diacetate (6 mg/kg b.w. daily) significantly increases the amounts of excreted 3alpha-hydroxy-5alpha-pregnan-20-one and A-homo-3-oxa-5alpha-pregnane-4,20-dione in urine in female rats. Significant increase in the weights of pituitary, liver and kidneys are noted in rats treated with ethynodiol diacetate (6 mg/kg b.w. daily). Norgestrel (75 μg/day) and ethynodiol diacetate (150 μg/day), co-administered with ethinyl estradiol (7.5 μg/day), lowers the plasma concentrations of HDL cholesterol in cynomolgus monkeys.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/E408955.html
关键字： 8080 CB;19-Norpregn-4-en-20-yne-3,17-diol, 3,17-diacetate, (3β,17α)-
上海阿拉丁生化科技股份有限公司是A股上市公司（（股票代码：688179），专注于科研试剂的研发、生产和销售，已陆续建立多个工厂和研发中心。作为领军企业，阿拉丁始终坚持质量第一，连续13年被评为“最受欢迎试剂品牌”。
阿拉丁目前常备库存试剂产品品种超过7万种，SKU总数超过46万，产品线涵盖了化学试剂、生化试剂、药靶配体、蛋白质和抗体等多个领域，是国内少数化学试剂到生物试剂全面发展的国产试剂品牌，产品同步发布在我们国内外电商平台。