中文名：萜烯七脂酸
英文名：Heptelidic acid (Koningic acid)
中文别名：(5aS,6R,9S,9aS)-1-氧-6-丙-2-基螺[3,5a,6,7,8,9a-六氢-2-苯并xepine-9,2'-环氧乙烷]-4-羧酸|(+)-萜烯七脂酸
纯度：≥95%
货号：H275171
包装：1mg
Cas号：74310-84-2
存储温度：-20°C储存,干燥
产品介绍：
product description：
Antibiotic .
Potent selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic site of GAPDH .
Anticancer compound . Selectively kills high-glycolytic cancer cells through glucose-dependent active ATP deprivation .
Antimalarial .
Apoptosis inhibitor. DNA fragmentation and caspase-3 activation inhibitor .
Selective and competitive inhibitor of mammalian DNA polymerases beta, lambda and terminal deoxynucleotidyl transferase (TdT) in family X of pols .
Reduces lactate secretion and causes reductions in overall protein synthesis and production of IFN-α and TNF.
application：
Heptalidic acid is a sesquiterpene lactone and found to inhibit etoposide-induced apoptosis in human leukemia U937 cells. In addition, it also inhibit mammalian DNA polymerases and terminal deoxynucleotidyl transferase.
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关键字： (5aS,6R,9S,9aS)-1-氧-6-丙-2-基螺[3,5a,6,7,8,9a-六氢-2-苯并xepine-9,2'-环氧乙烷]-4-羧酸;(+)-萜烯七脂酸
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