中文名:依碳酸氯替泼诺
英文名:Loteprednol etabonate
英文别名:(11β,17α)-7-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-androsta-1,4-diene-17-carboxylic acid chloromethyl ester
纯度:10mM in DMSO
货号:L408801
包装:1ml
Cas号:82034-46-6
存储温度:-80℃储存
产品介绍:
Information
Loteprednol etabonate Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
In vitro
Loteprednol possesses a metabolically labile function, the 17beta-ester, that is designed to be rapidly deactivated in the systemic circulation. Loteprednol etabonate exhibits a binding affinity which is 4.3 times that of dexamethasone, both compounds having a Hill factor close to 1 whereas PJ90 and PJ91 does not show any affinity to the receptor.
In vivo
Loteprednol etabonate administrated directly into the joint effectively blocks the inflammatory response. Loteprednol etabonate prevents the adverse inflammatory effects of antigen action in a rabbit acute experimental model for arthritis. Loteprednol etabonate (LE) (oral) reaches the upper GI tract effectively, but not the colon, due to absorption and/or decomposition in rats. Loteprednol etabonate (LE) shows a rapid, dose-dependent elimination with a total blood clearance (CLtotal) of higher than 60 ml/min/kg in rats. Loteprednol etabonate absorbes systemically, after topical administration, can be rapidly transformed to the inactive metabolites, and eliminates from the body mainly through the bile and urine.
Cell Data
cell lines:
Concentrations:
Incubation Time:
Powder Purity:≥99%
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关键字: (11β,?17α)?-7-?[(ethoxycarbonyl)?oxy]?-?11-?hydroxy-?3-?oxo-androsta-?1,?4-?diene-?17-?carboxylic acid chloromethyl ester
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