中文名:6-巯基嘌呤 (6-MP)
英文名:Mercaptopurine (6-MP)
英文别名:3H-purine-6(7H)-thione
纯度:10mM in DMSO
货号:M409022
包装:1ml
Cas号:50-44-2
存储温度:-80℃储存
产品介绍:
Information
Mercaptopurine (6-MP) Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.In vitro
Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA . Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis.
In vivo
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Powder Purity:≥99%
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