5'-Octyltocopherol (C8) CE-Phosphoramidite
Phosphoramidite used to incorporate a tocopherol modification at the 5' end of an oligonucleotide, with a C8 spacer.
Potential use in aiding cell delivery for nucleic acid therapeutics.
Includes a C8 spacer to minimise steric effects.
When used with a C6 S-S thiol, the tocopherol can be cleaved via the disulphide bridge, for example once the oligo has been delivered to the cell.
Has additional applications in the purification of ribozymes and thiol-modified oligos.
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