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FAP产品信息
英文名称:Fibroblast activation protein alpha
中文名称:成纤维细胞激活蛋白α
靶点别称:FAP,FAP alpha,SIMP,Seprase,APCE
物种:Human / Mouse / Cynomolgus / Rat
属性:Protein / Beads
标记:Biotin-labeled / FITC Labeled / Unconjugated / PE Labeled
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
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FAP分子背景
FAP(也称为seprase)是一种II型跨膜丝氨酸蛋白酶。质膜和可溶性形式都表现出脯氨酸切割后的内肽酶活性,对Ala/Ser-Gly-Pro-Ser/Asn/Ala共有序列有明显的偏好。也降解明胶,热变性I型胶原蛋白。还具有二肽基肽酶活性,优选Ala-Pro、Ile-Pro、Gly-Pro、Arg-Pro和Pro-Pro。质膜形式与DPP4、PLAUR或整合素结合,参与细胞外基质(ECM)的细胞周蛋白水解,从而促进细胞通过ECM的粘附、迁移和侵袭。通过降解短链蛋白多糖促进胶质瘤细胞通过脑实质的侵袭。通过以丝氨酸蛋白酶活性无关的方式调节细胞增殖和存活,在黑素细胞中充当肿瘤抑制因子。
FAP用户评价
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关键字: FAP;FAP蛋白;FAP重组蛋白;成纤维细胞激活蛋白α;FAP alpha;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。