Product Name:TAT-cyclo-CLLFVY
CAS No.:1446322-66-2
Synonyms:二聚抑制剂多肽
Catalog No.:217P651
Brand:HongTide(上海鸿肽生物)
Description:TAT-cyclo-CLLFVY是一种具有二硫键和环状结构的二聚抑制剂多肽,具有一定选择性。可以阻断重组HIF-1α与HIF-1β(IC50=1.3μM)的蛋白-蛋白质相互作用,但不能阻断HIF-2α与HIF-1β的蛋白相互作用。能抑制缺氧诱导的HIF-1活性,降低骨肉瘤和乳腺癌细胞中VEGF和CAIX的表达。还可减少缺氧HUVECs的小管化。
TAT-cyclo-CLLFVY is a dimeric inhibitor peptide with disulfide bonds and a cyclic structure, which has certain selectivity. Can block recombinant HIF-1 α Same as HIF-1 β (IC50=1.3) μ M) Protein protein interactions, but cannot block HIF-2 α Same as HIF-1 β Protein interactions. It can inhibit hypoxia induced HIF-1 activity, and reduce the expression of VEGF and CAIX in osteosarcoma and breast cancer cells. It can also reduce the tubulation of hypoxic HUVECs.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | CGRKKRRQRRRPPQ;cyclo(CLLFVY) (Disulfide bridge:Cys1-Cys1') |
Sequence(3-letter code) | H-Cys-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-OH;cyclo(H-Cys-Leu-Leu-Phe-Val-Tyr-OH) (Disulfide bridge:Cys1-Cys1') |
Peptide Structure |
|
Molecular Formula | C111H188N42O24S2 |
Molecular Weight | 2559.12 |
订购联系方式:
上海鸿肽生物科技有限公司
手机: +86-18018095145 (同微信号)
QQ: 3259098395
邮箱:sales1@hongtide.com
关键字: TAT-cyclo-CLLFVY ;1446322-66-2;二聚抑制剂多肽;多肽;多肽合成;
上海鸿肽生物科技有限公司(简称:鸿肽生物)是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖:定制多肽、目录多肽、氨基酸衍生物、小分子化合物;公司自成立以来,秉持“用质量作船, 以服务为帆,为科研服务”的企业理念,为国内外众多科研工作者提供了优质的服务及产品。