Glypican 2产品信息
英文名称:Glypican-2
中文名称:磷脂酰肌醇蛋白2
靶点别称:Glypican 2,GPC2
物种:Human/Mouse/Rhesus macaque
属性:Protein
标记:Unconjugated
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>90% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
Glypican 2用户评价
Glypican 2分子背景
Glypican 2(GPC2),也称为脑多糖,是一种在发育中的神经系统中发现的与糖磷脂酰肌醇连接的完整膜硫酸乙酰肝素蛋白多糖。脑聚糖参与细胞粘附,被认为调节轴突的生长和引导。脑聚糖对层粘连蛋白-1具有特别高的亲和力。GPC2沉默使Wnt/β-catenin信号失活,并降低神经母细胞瘤发生的致癌驱动因素N-Myc的表达。靶向GPC2的免疫毒素和嵌合抗原受体(CAR)T细胞在小鼠模型中抑制神经母细胞瘤的生长。GPC3特异性抗体-药物偶联物(ADC)也可以抑制神经母细胞瘤细胞增殖。
关键字: Glypican 2;Glypican 2蛋白;Glypican 2重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。