Product Name：Cortistatin 17, human
CAS No.：189450-19-9
Synonyms：人源皮质抑素-17
Catalog No.：182P13
Brand：HongTide（上海鸿肽生物）
Description：Cortistatin 17, human是由17个氨基酸组成的环状多肽，显示出与生长抑素的结构相似性。Cortistatin 17, human以与大鼠皮质抑素相似的方式与所有生长抑素受体亚型 (SSTR) 结合。 其对表达 SSTR2-5 的中国仓鼠卵巢细胞中毛喉素刺激的 cAMP 产生的抑制作用是剂量依赖性的，但比生长抑素 14 的效果略低。与大鼠皮质抑素一样，Cortistatin 17, human对大鼠的睡眠和觉醒模式有影响。Cortistatin 17, human以剂量依赖的方式减少轻度慢波睡眠（SWS1）并增加深度慢波睡眠（SWS2）。Cortistatin 17, human的施用导致皮质和海马脑电图暂时变平。
Cortistatin 17, human, is a cyclic peptide composed of 17 amino acids, exhibiting structural similarity to somatostatin. Cortistatin 17 binds to all somatostatin receptor subtypes (SSTR) in a similar manner to rat corticostatin. Its inhibitory effect on cAMP production stimulated by hirsutin in Chinese hamster ovarian cells expressing SSTR2-5 is dose-dependent, but slightly lower than the effect of somatostatin 14. Like rat corticostatin, Cortistatin 17, human has an impact on sleep and wakefulness patterns in rats. Cortistatin 17, human reduces mild slow wave sleep (SWS1) and increases deep slow wave sleep (SWS2) in a dose-dependent manner. The use of Cortistatin 17 and human resulted in temporary flattening of cortical and hippocampal electroencephalograms.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | DRMPCRNFFWKTFSSCK(Disulfide bridge：Cys5-Cys16) |
Sequence(3-letter code) | H-Asp-Arg-Met-Pro-Cys-Arg-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH(Disulfide bridge Cys5-Cys16) |
Peptide Structure | 
|
Molecular Formula | C96H139N27O24S3 |
Molecular Weight | 2151.54 |
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上海鸿肽生物科技有限公司
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邮箱：sales1@hongtide.com
关键字： 189450-19-9;人源皮质抑素-17;Cortistatin 17, huma;多肽;多肽合成;
上海鸿肽生物科技有限公司（简称：鸿肽生物）是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖：定制多肽、目录多肽、氨基酸衍生物、小分子化合物；公司自成立以来，秉持“用质量作船， 以服务为帆，为科研服务”的企业理念，为国内外众多科研工作者提供了优质的服务及产品。