Human LRRC15-coupled Magnetic Beads
背景(Background)
LRRC15 (Leucine-rich repeat-containing protein 15) is also known as LIB and hLib. LRRC15 is highly expressed in a variety of solid tumors. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). LRRC15 expression was induced by TGFβ on activated fibroblasts (αSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or cancers of mesenchymal origin. ABBV-085 is a monomethyl auristatin E (MMAE)-containing antibody–drug conjugate (ADC) directed against LRRC15, and it demonstrated robust preclinical efficacy against LRRC15 stromal-positive/cancer-negative, and LRRC15 cancer-positive models as a monotherapy, or in combination with standard-of-care therapies.
应用说明(Application)
This product is labeled by APC and coupled by CD47 protein in advance, no need to use fluorescent labeled secondary antibody, easy to flow cytometry.
The Isotype control (Cat. No. SMB-B01) is sold separately.
重构方法(Reconstitution)
See Certificate of Analysis (CoA) for detailed instruction.
存储(Storage)
Store beads at 2° to 8°C and protected from direct light. Do not use after the expiration date shown on the label.
Please avoid more than 3 freeze-thaw cycles. Immediate use after reconstitution is highly recommended.
制剂(Formulation)
Please contact us for detailed information.
Contact us for customized product form or formulation.
关键字: LRRC15磁珠;LRRC15 Beads;Magnetic Beads;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。