Product Name：FNIII14
CAS No.：206536-96-1
Synonyms：纤连蛋白样肽FNIII14
Catalog No.：218P852
Brand：HongTide（上海鸿肽生物）
Description：FNIII14是一种来源于纤连蛋白的第14个III型纤连蛋白样（FN-III）重复序列的肽，是由21个氨基酸组成的多肽，该功能位点通常被构象变化和蛋白水解切割所隐藏但暴露。FNIII14可以将β1-整合素从活性形式转换为非活性形式，通过与传统拮抗剂不同的机制导致整合素信号的功能失活。肽FNIII14对β1-整合素的灭活在体外和体内对各种实体瘤和血液系统恶性肿瘤具有强大的抗癌作用，包括抑制存活、增殖、迁移、侵袭和myc表达，增强其他抗癌症活性，抑制转移，抑制细胞粘附介导的对阿糖胞苷的耐药性，以及抑制肿瘤发作。
FNII14 is a peptide derived from the 14th type III fibronectin like (FN-III) repeat sequence of fibronectin. It is a polypeptide composed of 21 amino acids, and this functional site is usually hidden but exposed by conformational changes and proteolytic cleavage. FNII14 can convert β 1-integrin from its active form to its inactive form, leading to functional inactivation of integrin signaling through a different mechanism than traditional antagonists. Peptide FNII14 has a strong anti-cancer effect on various solid tumors and hematological malignancies in vitro and in vivo by inactivating β 1-integrin, including inhibiting survival, proliferation, migration, invasion, and myc expression, enhancing other anti-cancer activities, inhibiting metastasis, inhibiting cell adhesion mediated resistance to cytarabine, and inhibiting tumor attacks.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | TEATITGLEPGTEYTIYVIAL |
Sequence(3-letter code) | H-Thr-Glu-Ala-Thr-Ile-Thr-Gly-Leu-Glu-Pro-Gly-Thr-Glu-Tyr-Thr-Ile-Tyr-Val-Ile-Ala-Leu-OH |
Peptide Structure | 
|
Molecular Formula | C103H163N21O35 |
Molecular Weight | 2254.16 |
订购联系方式：
上海鸿肽生物科技有限公司
手机： +86-18018095145 （同微信号）
QQ: 3259098395
邮箱：sales1@hongtide.com
关键字： 206536-96-1;FNIII14 ;纤连蛋白样肽FNIII14;多肽;多肽合成;
上海鸿肽生物科技有限公司（简称：鸿肽生物）是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖：定制多肽、目录多肽、氨基酸衍生物、小分子化合物；公司自成立以来，秉持“用质量作船， 以服务为帆，为科研服务”的企业理念，为国内外众多科研工作者提供了优质的服务及产品。