Human IL-2 Protein, Tag Free (MALS verified)
分子别名(Synonym)
IL2,TCGF,lymphokine,Interleukin 2
表达区间及表达系统(Source)
Human IL-2 Protein, Tag Free (IL2-H5215) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Thr 153 (Accession # P60568-1).
Predicted N-terminus: Ala 21
蛋白结构(Molecular Characterization)
![1.jpg 1.jpg](/SupplyImg1/2024-07-03/6385561431051714593255665.jpg)
This protein carries no "tag".
The protein has a calculated MW of 15.4 kDa. The protein migrates as 14 kDa and 16-17 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 0.01 EU per μg by the LAL method.
宿主蛋白残留(Host Cell Protein)
<0.5 ng/µg of protein tested by ELISA.
宿主核酸残留(Host Cell DNA)
<0.02 ng/μg of protein tested by qPCR.
无菌(Sterility)
Negative
支原体(Mycoplasma)
Negative.
纯度(Purity)
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
![2.jpg 2.jpg](/SupplyImg1/2024-07-03/6385561431838109155590767.jpg)
![3.jpg 3.jpg](/SupplyImg1/2024-07-03/6385561432118613369349088.jpg)
背景(Background)
白细胞介素-2(IL-2)是一种白细胞介素,一种细胞因子免疫系统信号分子,是一种白细胞营养激素,有助于身体对微生物感染的自然反应,并区分外来(非自我)和自我。IL-2通过与负责免疫的淋巴细胞表达的IL-2受体结合来介导其作用。成熟的人IL-2分别与小鼠和大鼠IL-2具有56%和66%的氨基酸序列同一性。人和小鼠IL-2表现出跨物种活性。IL-2受体由三个亚基组成,这些亚基以不同的预先形成的复合物存在于细胞表面。在胸腺T细胞发育过程中,IL-2对于称为调节性T细胞(T-regs)的独特T细胞亚群的成熟也是必需的。T-Regs通过阻止反应细胞产生IL-2来实现。因此,IL-2需要区分自我和非自我,这是免疫系统的另一个独特特征。
关键字: IL-2;IL-2蛋白;IL-2重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。