Human Mesothelin / MSLN (296-580) Protein, His Tag, premium grade
分子别名(Synonym)
MSLN,Mesothelin,MPF
表达区间及表达系统(Source)
Human Mesothelin (296-580), His Tag, premium grade (MSN-H522a) is expressed from human 293 cells (HEK293). It contains AA Glu 296 - Gly 580 (Accession # AAH09272).
Predicted N-terminus: Glu 296
它是在我们严格的质量控制体系下生产的,该体系包括一套全面的检测,包括无菌和内毒素检测。在临床前早期阶段,仔细验证产品性能,并测试其与细胞培养用途或任何其他应用的兼容性。当准备好过渡到后期临床阶段时,我们还提供定制的GMP蛋白质服务,以满足您的需求。我们将与您合作,根据您的要求定制和开发GMP级产品,该产品也符合细胞治疗的细胞制造中使用的原材料和辅助材料的要求。
蛋白结构(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 33.0 kDa. The protein migrates as 38-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 0.01 EU per μg by the LAL method.
无菌(Sterility)
Negative
支原体(Mycoplasma)
Negative.
纯度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
间皮素(MSLN)也被称为CAK1抗原,前巨核细胞增强因子,属于间皮素家族。间皮素/MSLN可以通过弗林样转化酶蛋白水解切割成以下两条链:巨核细胞增强因子(MPF)和切割形式的间皮素。MPF和间皮素的裂解形式都是N-糖基化的。间皮素/MSLN可以与MUC16相互作用。膜锚定形式的MSLN可能在细胞粘附中发挥作用。MPF在体外增强巨核细胞集落的形成。
关键字: Mesothelin;Mesothelin蛋白;Mesothelin重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。