Human IL-12 Protein, premium grade
分子别名(Synonym)
IL12,p70,Interleukin-12
表达区间及表达系统(Source)
Human IL-12 Protein, premium grade (IL2-H5210) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Ser 328 & Arg 23 - Ser 219 (Accession # P29460-1 & P29459-1).
Predicted N-terminus: Ile 23
专为临床前阶段设计的premium级重组人IL-12蛋白(IL2-H5210)与GMP级重组人IL-12(GMP-L12H23)具有相同的活性和性能,能够实现从临床前发展到临床阶段的无缝过渡。在原材料安全不是首要任务的早期开发阶段,premium级产品为GMP级产品提供了一种经济高效的替代品。通过在早期开发阶段使用高级产品,您可以轻松过渡到临床和商业阶段,而无需重新验证原材料和修改生产流程。
蛋白结构(Molecular Characterization)
This protein carries no "tag".
The protein has a calculated MW of 58.9 kDa. The protein migrates as 76 kDa±3 kDa under reducing (R) condition, and 69 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 0.01 EU per μg by the LAL method.
宿主蛋白残留(Host Cell Protein)
<0.5 ng/µg of protein tested by ELISA.
宿主核酸残留(Host Cell DNA)
<0.02 ng/μg of protein tested by qPCR.
无菌(Sterility)
Negative
支原体(Mycoplasma)
Negative.
纯度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 24 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
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背景(Background)
白细胞介素12(IL-12)也称为p70,是一种由树突状细胞、巨噬细胞和人类B淋巴细胞样细胞(NC-37)响应抗原刺激而自然产生的白细胞介质。IL-12是一种异二聚体细胞因子,含有IL-12A(p35)和IL-12B(p40)。IL-12参与将幼稚T细胞分化为Th1细胞。它被称为T细胞刺激因子,可以刺激T细胞的生长和功能。它刺激T细胞和NK细胞产生IFN-γ和TNF-α,并减少IL-4介导的对IFN-γ的抑制。IL-12在自然杀伤细胞和T淋巴细胞的活性中起着重要作用。IL-12还具有抗血管生成活性,这意味着它可以阻断新血管的形成。
关键字: IL-12;IL-12蛋白;IL-12重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。