Human IL-21 Protein, premium grade
分子别名(Synonym)
IL21,Za11,Interleukin-21
表达区间及表达系统(Source)
Human IL-21, premium grade (IL1-H5213) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 162 (Accession # Q9HBE4-1).
Predicted N-terminus: Gln 30
重组人IL-21,premium级(IL1-H5213),专为临床前阶段设计,具有与GMP级重组人IL-21(GMP-L21H25)相同的活性和性能,可实现从临床前开发到临床阶段的无缝过渡。在原材料安全不是首要任务的早期开发阶段,premium级产品为GMP级产品提供了一种经济高效的替代品。通过在早期开发阶段使用Premium级产品,您可以轻松过渡到临床和商业阶段,而无需重新验证原材料和修改制造工艺。
蛋白结构(Molecular Characterization)
![1.jpg 1.jpg](/SupplyImg1/2024-07-12/6385638763430145075167239.jpg)
This protein carries no "tag".
The protein has a calculated MW of 15.5 kDa. The protein migrates as 16 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 0.01 EU per μg by the LAL method.
宿主蛋白残留(Host Cell Protein)
<0.5 ng/µg of protein tested by ELISA.
宿主核酸残留(Host Cell DNA)
<0.02 ng/μg of protein tested by qPCR.
无菌(Sterility)
Negative
支原体(Mycoplasma)
Negative.
纯度(Purity)
>95% as determined by SDS-PAGE.
>95% as determined by SEC-HPLC.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
![2.jpg 2.jpg](/SupplyImg1/2024-07-12/6385638764753419887858539.jpg)
![3.jpg 3.jpg](/SupplyImg1/2024-07-12/6385638765037925841155053.jpg)
背景(Background)
白细胞介素-21(IL-21)是一种分泌蛋白,属于IL-15/IL-21家族。白细胞介素-21/IL-21属于细胞因子家族,与由私人受体(IL21R)和常见细胞因子受体γ链(γ(C))组成的复合受体结合。白细胞介素-21/IL-21影响多种细胞类型,包括CD8+记忆T细胞、NK细胞和CD4记忆T细胞亚群。IL-21R广泛分布于淋巴造血细胞上。IL-21是CD4+T细胞在抗原刺激下产生的多效性细胞因子。它的作用通常会增强免疫细胞的抗原特异性反应。IL-21促进CD8+T细胞和NK细胞的抗肿瘤活性。IL-21通过与特定的I型细胞因子受体IL-21R结合发挥其作用,IL-21R还含有在其他细胞因子受体中发现的γ链(γc),包括IL-2、IL-4、IL-7、IL-9和IL-15。IL-21/IL-21R相互作用触发一系列事件,包括酪氨酸激酶JAK1和JAK3的激活,随后是转录因子STAT1和STAT3的激活。
关键字: IL-21;IL-21蛋白;IL-21重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。