Human IL-17F Protein, His Tag (MALS verified)
分子别名(Synonym)
IL-17F,Interleukin-17F,Cytokine ML-1
表达区间及表达系统(Source)
Human IL-17F, His Tag (ILF-H5244) is expressed from human 293 cells (HEK293). It contains AA Arg 31 - Gln 163 (Accession # Q96PD4-1).
Predicted N-terminus: His
蛋白结构(Molecular Characterization)
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 16.8 kDa. The protein migrates as 22-25 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
白细胞介素-17F(IL17F)也称为白细胞介蛋白-24(IL24)、细胞因子ML-1,是一种分泌的二硫键连接的同二聚体,属于IL-17家族。在人类和小鼠中,IL-17家族至少有六个成员:IL-17A、IL-17B、IL-17C、IL-17D、IL-17E(也称为IL-25)和IL-17F(也称为IL-24)。IL-17代表了一个结构相关的细胞因子家族,它们共享一个高度保守的C末端区域,但在N末端区域和不同的生物学作用上彼此不同。IL-17F/IL-24在活化的CD4+T细胞和活化的单核细胞中表达,但在静息状态下不表达。IL17F/白细胞介素-24刺激其他细胞因子如IL-6、IL-8和粒细胞集落刺激因子的产生,并可以调节软骨基质的周转。IL17F/IL-24刺激PBMC和T细胞增殖并抑制血管生成。IL17F缺陷是家族性6型念珠菌病(CANDF6)的原因。
关键字: IL-17F;IL-17F蛋白;IL-17F重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。