Human IL-2 R alpha / CD25 Protein, His Tag
分子别名(Synonym)
IL2RA,CD25,p55,IL2-RA,IL-2-RA
表达区间及表达系统(Source)
Human IL-2 R alpha, His Tag (ILA-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 22 - Cys 213 (Accession # NP_000408).
Predicted N-terminus: Glu 22
蛋白结构(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 23.6 kDa. The protein migrates as 34-46 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
白细胞介素-2受体亚基α(IL2RA)也称为IL-2R亚基α、IL-2-RA、IL2-RA、TAC抗原、p55、CD抗原CD25,是一种I型跨膜糖蛋白。IL2RA在活化的T细胞和调节性T细胞上表达,并且能够自身以低亲和力结合IL2。然而,当IL2RA与IL2受体β链和γ链非共价结合,随后启动MAPK或JAK/STAT等细胞内信号通路时,会产生配体诱导的高亲和力异三聚体受体复合物。在树突状细胞(DC)上,CD25以前被认为是一种激活标志物,而小鼠和人类DC都可以表达CD25,但它们不表达IL-2受体的β链,这是执行IL-2信号传导所必需的。
关键字: IL2RA;IL2RA蛋白;IL2RA重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。