Human FOLR2 Protein, His Tag
分子别名(Synonym)
FOLR2,BETA-HFR,FBP,PL-1,FR-BETA,FR-P3,FBP
表达区间及表达系统(Source)
Human FOLR2, His Tag (FO2-H5223) is expressed from human 293 cells (HEK293). It contains AA Thr 17 - His 228 (Accession # P14207-1).
Predicted N-terminus: Thr 17
蛋白结构(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 26.5 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to N-linked glycosylation which has been verified by PNGase F digestion.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>90% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in Tris and Glycine, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
叶酸受体β也称为叶酸受体2、FBP、FOLR2、beta-HFR、FBP/PL-1、FR-beta、FR-P3,是叶酸受体(FOLR)家族的成员。并介导5-甲基四氢叶酸向细胞内部的递送。该蛋白分别与FOLR1和FOLR3蛋白具有68%和79%的序列同源性。FOLR2蛋白最初被认为只存在于胎盘中,但也在脾脏、骨髓和胸腺中检测到。FOLR2主要在胎盘、中性粒细胞谱系细胞和一些CD34+造血祖细胞中表达。它在髓系白血病、头颈部鳞状细胞癌和几种非上皮性癌症中上调。它也在慢性炎症部位的巨噬细胞和单核细胞上上调,包括类风湿性关节炎滑膜和胶质母细胞瘤。FOLR2是M-CSF存在下产生的巨噬细胞的标志物,但不是GM-CSF。其表达与叶酸摄取能力的增强有关。治疗药物的叶酸偶联物是靶向肿瘤相关巨噬细胞的潜在免疫治疗工具。
关键字: FOLR2;FOLR2蛋白;FOLR2重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。