Human TDP-43 Protein, His Tag
分子别名(Synonym)
TAR DNA-binding protein 43
表达区间及表达系统(Source)
Human TDP-43, His Tag (TD3-H5145) is expressed from E. coli cells. It contains AA Met 1 - Met 414 (Accession # Q13148-1).
Predicted N-terminus: Met
蛋白结构(Molecular Characterization)
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 46.8 kDa. The protein migrates as 54-56 kDa under reducing (R) condition (SDS-PAGE).
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>90% as determined by SDS-PAGE.
制剂(Formulation)
Supplied as 0.2 μm filtered solution in 50 mM HEPES, 500 mM NaCl, 0.4 M Arginine, pH8.0 with glycerol as protectant.
Contact us for customized product form or formulation.
运输(Shipping)
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存储(Storage)
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product MUST be stored at -70°C or lower upon receipt;
-70°C for 12 months under sterile conditions.
背景(Background)
TDP-43是一种分子量为43KDa的反式反应(TAR)-D结合蛋白,由位于1号染色体上的TARDBP基因编码。它是一种R/D结合蛋白,在结构上类似于典型的hnRNP蛋白家族成员。参与转录调控和R加工。它与散发性和家族性肌萎缩侧索硬化症和额颞叶变性有关。TDP-43主要是核的,但在病理条件下会转移到细胞质中。TDP-43蛋白病的主要标志是细胞质积累、磷酸化、泛素化和截断。
关键字: TDP-43;TDP-43蛋白;TDP-43重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。