Human IL-6 R alpha / CD126 Protein, Fc Tag
分子别名(Synonym)
IL6R,CD126,IL-6R-1,IL-6RA,IL6RA,IL-6R-alpha,IL6RQ,gp80
表达区间及表达系统(Source)
Human IL-6 R alpha, Fc Tag (ILR-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - Pro 365 (Accession # P08887-1).
Predicted N-terminus: Leu 20
蛋白结构(Molecular Characterization)
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 65.0 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
白细胞介素6受体(IL6R)也称为CD126(分化簇126),是一种强效的多效性细胞因子,调节各种组织的细胞生长和分化,尤其因其在免疫反应和急性期反应中的作用而闻名。IL6R是由IL-6受体亚基(IL6R)和白细胞介素6信号转导子糖蛋白130组成的蛋白质复合物。IL6R也表示编码该亚基的人类基因。有报道称,编码不同异构体的剪接转录变体。IL6R亚基也被许多其他细胞因子共享。IL6R的可溶性形式来源于膜结合IL6Rα的蛋白水解切割,并通过使IL6配体可与信号转导子gp130接触而起激动作用。IL6和IL6R的失调产生与多种炎性疾病和恶性肿瘤的发病机制有关,如多发性骨髓瘤、类风湿性关节炎或骨质疏松症,据报道,人源化抗IL6R单克隆抗体是一种有前景的药物,适用于IL6驱动的疾病的治疗方法。白细胞介素-6受体已被证明与白细胞介蛋白-6和睫状神经营养因子相互作用。
关键字: IL6R;IL6R蛋白;IL6R重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。