Human DPPIV / CD26 Protein, His Tag, active dimer (active enzyme, MALS verified)
分子别名(Synonym)
DPP4,ADABP,ADCP2,CD26,DPPIV,TP103
表达区间及表达系统(Source)
Human DPPIV, His Tag (DP4-H5221) is expressed from human 293 cells (HEK293). It contains AA Asp 34 - Pro 766 (Accession # NP_001926.2).
Predicted N-terminus: Asp 34
蛋白结构(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 85.7 kDa. The protein migrates as 95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
二肽基肽酶IV(DPPIV)也称为腺苷脱氨酶复合蛋白2,DPPIV或CD26是大多数细胞类型表面表达的抗原酶,与免疫调节、信号转导和凋亡有关。它是一种内在的膜糖蛋白和丝氨酸外肽酶,从多肽的N端切割X-脯氨酸二肽。DPPIV的底物是含脯氨酸(或丙氨酸)的肽,包括生长因子、趋化因子、神经肽和血管活性肽。DPPIV在葡萄糖代谢中起着重要作用。它负责肠促胰岛素如GLP-1的降解。DPPIV在肿瘤生物学中起着重要作用,可用作各种癌症的标志物,其在细胞表面或血清中的水平在某些肿瘤中升高,在另一些肿瘤中降低。DPPIV还特异性地和高亲和力地结合腺苷脱氨酶。这种互动的意义尚未确定。
关键字: DPPIV;二肽基肽酶IV;DPPIV酶;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。