Human TACI / TNFRSF13B Protein, His Tag
分子别名(Synonym)
CD267,TACI,TNFRSF13B
表达区间及表达系统(Source)
Human TACI, His Tag (TAI-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 2 - Thr 166 (Accession # O14836-1).
蛋白结构(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 20.5 kDa. The protein migrates as 19-22 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
跨膜激活剂和CAML相互作用物(TACI),也称为肿瘤坏死因子受体超家族成员13B(TNFRSF13B)。最初发现它是因为它能够与钙调节剂和亲环素配体(CAML)相互作用。后来发现TACI通过与TNF家族的两个成员BAFF和APRIL相互作用,在体液免疫中起着至关重要的作用。
本研究表明,在非小细胞肺癌中,增殖诱导配体(APRIL)、B细胞成熟抗原(BCMA)和跨膜激活物和CAML相互作用物(TACI)蛋白通过免疫组织化学、逆转录定量聚合酶链式反应和蛋白质印迹异常表达。此外,观察到APRIL、BCMA和TACI的表达参与了A549细胞中细胞外信号调节激酶(ERK)1/2的激活。
关键字: TACI;TACI蛋白;TACI重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。