Human ICOS / CD278 (C136S, C137S) Protein, His Tag, active dimer (MALS verified)
分子别名(Synonym)
ICOS,CD278,AILIM,Inducible T-cell costimulator
表达区间及表达系统(Source)
Human ICOS Protein, His Tag (ICS-H52Ha) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Phe 141 (Accession # Q9Y6W8-1 (C136S,C137S)).
蛋白结构(Molecular Characterization)
The protein has a calculated MW of 19.1 kDa. The protein migrates as 25-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
诱导性T细胞共刺激物(ICOS)也称为活化诱导性淋巴细胞免疫介导分子(AILIM)CD278,属于CD28家族的免疫共刺激受体,由CD28、CTLA-4和PD-1组成。ICOS增强了T细胞对外来抗原的所有基本反应,即增殖、淋巴因子的分泌、介导细胞间相互作用的分子的上调,以及有效帮助B细胞分泌抗体。CD278/ICOS可防止预激活T细胞的凋亡,并在CD40介导的免疫球蛋白同种型的类别转换中发挥关键作用。
关键字: ICOS;ICOS蛋白;ICOS重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。