Product Name:α-Conotoxin GID
CAS No.:547741-78-6
Synonyms:麻痹肽神经毒素多肽α-Conotoxin GID
Catalog No.:218P939
Brand:HongTide(上海鸿肽生物)
Description:α-Conotoxin GID 是一种麻痹肽神经毒素,是由19个氨基酸组成的环状多肽,是 nAChR 的选择性拮抗剂,IC50 为 5 nM (α7)、3 nM (α3β2),150 nM (α4β2)。α-Conotoxin GID 是一种富含二硫键的小肽,具有抑制慢性疼痛的潜力。α-Conotoxin GID 含有 C 端羧酸酯,因此用 C 端羧酰胺取代会导致 α4β2 nAChR 丢失。α-Conotoxin GID 可以从芋螺属物种中分离出来。
Alpha Notoxin GID is a numbing peptide neurotoxin composed of a cyclic peptide of 19 amino acids. It is a selective antagonist of nAChR with IC50 values of 5 nM (α 7), 3 nM (α 3 β 2), and 150 nM (α 4 β 2). Alpha Notoxin GID is a small peptide rich in disulfide bonds that has the potential to inhibit chronic pain. The α - Coronation GID contains a C-terminal carboxylic acid ester, so replacing it with a C-terminal carboxylic acid amide will result in the loss of α 4 β 2 nAChR. The α - Notoxin GID can be isolated from species of the Conus genus.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | IRD-{Gla}-CCSNPACRVNN-{Hyp}-HVC (Disulfide bridge:Cys5-Cys11, Cys6-Cys19) |
Sequence(3-letter code) | Ile-Arg-Asp-{Gla}-Cys-Cys-Ser-Asn-Pro-Ala-Cys-Arg-Val-Asn-Asn-{Hyp}-His-Val-Cys (Disulfide bridge:Cys5-Cys11, Cys6-Cys19) |
Peptide Structure |
|
Molecular Formula | C84H132N30O31S4 |
Molecular Weight | 2186.39 |
订购联系方式:
上海鸿肽生物科技有限公司
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邮箱:sales1@hongtide.com
关键字: 547741-78-6;α-Conotoxin GID;麻痹肽神经毒素多肽α-Conotoxin;多肽;多肽合成;
上海鸿肽生物科技有限公司(简称:鸿肽生物)是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖:定制多肽、目录多肽、氨基酸衍生物、小分子化合物;公司自成立以来,秉持“用质量作船, 以服务为帆,为科研服务”的企业理念,为国内外众多科研工作者提供了优质的服务及产品。