氨萘非特|T6336|TargetMol

价格	￥218	￥319	￥535
包装	1mg	2mg	5mg

最小起订量	1mg
发货地	上海
更新日期	2024-09-29

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产品详情

中文名称:氨萘非特	英文名称:Amonafide
CAS:69408-81-7	品牌: TargetMol
产地: 美国	保存条件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
纯度规格: 99.39%	产品类别: 抑制剂
货号: T6336

Product Introduction

Bioactivity

名称	Amonafide
描述	Amonafide (NSC-308847,AS1413)(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.
细胞实验	All cell lines are in the logarithmic phase of growth when the assay of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) is carried out. Cells are harvested and seeded into 96-well tissue culture plates at a density of 2.5 × 103 cells/well in 150 μL aliquots of medium. The concentrations tested are serial dilutions of a stock solution (10 μM in DMSO) with phosphate-buffered saline (PBS) and are added 24 hours later. The assay is ended after 72 hours of Amonafide exposure and PBS is used as a negative control. After 72 hours treatment, cells are washed twice with PBS, and then 50 μL/well of MTT reagent (1 mg/mL in PBS) together with 150 μL/well of prewarmed medium are added. The plates are returned to the incubator for 4 hours. Subsequently, DMSO is added as solvent. Absorbance is determined at 570 nm with a Microplate reader. All experiments are performed at least three times, and the average of the percentage absorbance is plotted against concentration. Then, the concentration of Amonafide required to inhibit 50% of cell growth (IC50) is calculated for Amonafide.(Only for Reference)
体外活性	Through a topoisomerase II-mediated reaction, Amonafide treatment produces DNA single-strand breaks (SSB), double-strand breaks (DSB), and DNA-protein cross-links in human myeloid leukemia cells. Amonafide treatment inhibits conlony formation of the leukemic cell lines and the normal human bone marrow GM-CFC in a dose-dependent manner. Amonafide does not produce topoisomerase I-mediated DNA cleavage even at 100 μM. The m-AMSA-resistant line is less than 2-fold resistant to Amonafide [1] Amonafide interferes with the DNA breakage-reunion activity of mammalian DNA topoisomerase II resulting in DNA cleavage stimulation. [2] Compared with those of other antitumor drugs, Amonafide-stimulated cleavage intensity patterns are markedly different. Amonafide highly prefers a cytosine, and excludes guanines and thymines instead, at position -1, with lower preference for an adenine at position +1. [3] Topoisomerase II-mediated DNA cleavage induced by Amonafide is affected only slightly (less than 3-fold) by 1 mM ATP, suggeting that Amonafide is an ATP-insensitive topoisomerase II inhibitor in contrast to doxorubicin, etoposide, and mitoxantrone. [4] Amonafide significantly inhibits the growth of HT-29, HeLa, and PC3 cells with IC50 of 4.67 μM, 2.73 μM, and 6.38 μM, respectively. [5] Amonafide is unaffected by P-glycoprotein-mediated efflux, unlike those of the classical topoisomerase II inhibitors (daunorubicin, doxorubicin, idarubicin, etoposide, and mitoxantrone). [6]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 53 mg/mL (187.1 mM) Ethanol : 4 mg/mL (14.11 mM) H2O : < 1 mg/mL (insoluble or slightly soluble)
关键字	Topoisomerase \| NSC308847,AS-1413 \| NSC308847,AS 1413 \| Inhibitor \| inhibit \| AS-1413 \| AS 1413 \| Amonafide
相关产品	Prulifloxacin \| Norfloxacin \| Ciprofloxacin \| Irinotecan hydrochloride trihydrate \| Berberine chloride \| Etoposide \| Ciprofloxacin monohydrochloride \| EIDD-1931 \| Flumequine \| Enoxacin
相关库	抑制剂库 \| 抗乳腺癌化合物库 \| 抗癌活性化合物库 \| 经典已知活性库 \| 抗癌化合物库 \| 已知活性化合物库 \| 抗衰老化合物库 \| 药物功能重定位化合物库 \| 抗癌临床化合物库 \| 抗癌药物库

关键字：氨萘非特|||Quinamed|||Nafidimide|||AS1413|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	2013-04-18 （12年）	注册资本	566.265100万人民币
员工人数	100-500人	年营业额	￥ 1亿以上
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务	经营模式	贸易,工厂,试剂,定制,服务

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公司成立：12年
注册资本：566.265100万人民币
企业类型：有限责任公司(自然人投资或控股)
主营产品：小分子抑制剂、药物筛选化合物库、药物筛选等
公司地址：静安区江场三路238号8楼

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氨萘非特|T6336|TargetMol相关厂家报价

产品名称	价格		公司名称	报价日期
5-氨基-2-(2-(二甲基氨基)乙基)-1H-苯并[de]异喹啉-1,3(2H)-二酮	询价	VIP5年	河南威梯希化工科技有限公司	2024-11-15
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aladdin 阿拉丁 A126932 AS1413, 氨萘非特(Amonafide) 69408-81-7 ≥98%	￥338.90	VIP13年	上海阿拉丁生化科技股份有限公司	2024-10-31
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aladdin 阿拉丁 A408632 Amonafide 69408-81-7 10mM in DMSO	￥451.90	VIP1年	上海阿拉丁生化科技股份有限公司	2024-08-16
Amonafide	￥875		武汉科昊佳生物科技有限公司	2020-01-13
Amonafide	￥700		上海伟寰生物科技有限公司	2020-01-13
Amonafide	￥977.75		Selleck中国	2020-01-12

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