中文名称:
奥拉帕尼
英文名称:
olaparib
英文别名:
AZD-2281;
azd2281 Olaparib;
CAS号:
763113-22-0
分子式:
C24H23FN4O3
分子量:
434.46300
精确质量:
434.17500
PSA:
86.37000
Olaparib (AZD-2281, trade name Lynparza) is an FDA-approved targeted therapy for cancer, developed by KuDOS Pharmaceuticals and later by AstraZeneca. It is a PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which include some ovarian, breast, and prostate cancers. In December 2014, olaparib was approved for use as a single agent by the EMA and the FDA. The FDA approval is in for germline BRCA mutated (gBRCAm) advanced ovarian cancer that has received three or more prior lines of chemotherapy.
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