SC3319-25mg
TBA-354 (抗结核)
25mg
7467.00元
化学信息:
化学名
(6S)-2-nitro-6-[[6-[4-(trifluoromethoxy)phenyl]pyridin-3-yl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
别名
SN31354, TBA354, TBA 354
溶剂/溶解度
Water<1mg/ml; DMSO5mg/ml; Ethanol<1mg/ml
溶液配制
5mg加入1.15ml DMSO,或者每4.36mg加入1ml DMSO,配制成10mM溶液。SC3319-10mM用DMSO配制。
生物信息:
产品描述
TBA-354 is a potent anti-tuberculosis compound; maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates.
靶点
Anti-tuberculosis
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体外研究
TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates. TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy.
体内研究
TBA-354 has high bioavailability and a long elimination half-life. In vitro studies suggest a low risk of drug-drug interactions. Low-dose aerosol infection models of acute and chronic murine tuberculosis reveal time- and dose-dependent in vivo bactericidal activity that is at least as potent as that of delamanid and more potent than that of PA-824.
相关实验数据(此数据来自于公开文献,碧云天并不保证其有效性):
参考文献:
1. Upton AM, et al. Antimicrob Agents Chemother. 2015 Jan, 59(1), 136-44.
2. Tasneen R, et al. Antimicrob Agents Chemother. 2015 Jan, 59(1), 129-35.
包装清单:
SC3319-10mM
TBA-354 (抗结核)
10mM×0.2ml
SC3319-5mg
TBA-354 (抗结核)
5mg
SC3319-25mg
TBA-354 (抗结核)
25mg
保存条件:
-20℃保存,至少一年有效。5mg和25mg包装也可室温保存,至少6个月有效。如果溶于非DMSO溶剂,建议分装后-80℃保存,预计6个月内有效。
注意事项:
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
为了您的安全和健康,请穿实验服并戴一次性手套操作。