| 产品编号 |
产品名称 |
产品包装 |
产品价格 |
| P6173-100μg |
Recombinant Murine CDNF |
100μg |
2750.00元 |
|
Species
|
Gene ID
|
Accession
|
Source
|
Length
|
MW
|
Tag
|
|
Mouse
|
227526
|
Q8CC36
|
E. coli
|
163aa
|
18.5kDa
|
－
|
|
About this Antibody
|
|
Name
|
Recombinant Murine CDNF (Recombinant Murine Cerebral Dopamine Neurotrophic Factor; rMuCDNF)；Recombinant Mouse CDNF ; 重组小鼠大脑多巴胺神经营养因子
|
|
Synonyms
|
ARMETL1; arginine-rich, mutated in early stage tumors-like 1; ARMETL1; ARMET-like protein 1; cerebral dopamine neurotrophic factor; Conserved dopamine neurotrophic factor
|
|
Purity
|
>97% by SDS-PAGE and HPLC analyses.
|
|
Biological Activity
|
Fully biologically active when compared to standard. It is able to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons when immobilized at 5-30μg/ml on a nitrocellulose-coated microplate.
|
|
Physical Appearance
|
Sterile Filtered White lyophilized (freeze-dried) powder.
|
|
Formulation
|
Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4.
|
|
Endotoxin
|
Less than 0.1EU/μg of rMuCDNF as determined by LAL method.
|
|
Reconstitution
|
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.
|
|
Category
|
Cytokine
|
|
Background
|
Cerebral dopamine neurotrophic factor (CDNF), also known as ARMET-like protein 1, is a protein encoded by the CDNF gene and it is widely expressed in neuronal and non-neuronal tissues. The cerebral dopamine neurotrophic factor (CDNF) also is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). By research, CDNF prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons and it might be beneficial for the treatment of parkinson's disease. Recombinant murine CDNF contains 163 amino acid residues and it shares 81% and 87%a.a. sequence identity with human and rat CDNF.
|
|
Amino Acid Sequence
|
QGLEAGVGPR ADCEVCKEFL DRFYNSLLSR GIDFSADTIE KELLNFCSDA KGKENRLCYY LGATTDAATK ILGEVTRPMS VHIPAVKICE KLKKMDSQIC ELKYGKKLDL ASVDLWKMRV AELKQILQRW GEECRACAEK SDYVNLIREL APKYVEIYPQ TEL
|
包装清单:
|
产品编号
|
产品名称
|
包装
|
|
P6173-5μg
|
Recombinant Murine CDNF
|
5μg
|
|
P6173-25μg
|
Recombinant Murine CDNF
|
25μg
|
|
P6173-100μg
|
Recombinant Murine CDNF
|
100μg
|
|
P6173-1mg
|
Recombinant Murine CDNF
|
1mg
|
|
-
|
说明书
|
1份
|
保存条件:
-20℃或更低温度保存，至少一年有效。由于蛋白的每次冻融均会引起部分失活，所以首次配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液)，须分装后-20℃或更低温度冻存，以避免反复冻融。
注意事项:
由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。