AS-604850

AS-604850 is a selective, ATP-competitive inhibitor of PI3K.gamma. with IC50 values of 0.25, >20, >20, and 4.5 µM for the human recombinant .gamma., .delta., .beta., and .alpha. isoforms, respectively.{13338} AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.{13338}