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抑制剂描述:
产品名称:Epacadostat (INCB024360)
产品别名:INCB-024360,INCB 024360
英文别名:INCB-024360;INCB 024360
靶点:IDO1
CAS:1204669-58-8
纯度:>98%
外观:Powder
保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
描述:
Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. Phase 2.
溶解性:DMSO:87 mg/mL (198.52 mM)
Ethanol:53 mg/mL warmed (120.94 mM)
体外研究:
In IFN-γ–treated human HeLa cells, INCB024360 potently inhibits kynurenine production. INCB024360 also promotes T and natural killer (NK)-cell growth, increases IFN-gamma production, and reduces conversion to regulatory T (T(reg))-like cells.
体内研究:INCB024360 (100 mg/kg, p.o.), via IDO1 inhibition, suppresses kyn generation and tumor growth in immunocompetent, but not immunodeficient, mice. In mice bearing CT26 colon carcinoma, INCB024360 (100 mg/kg, p.o.) also inhibits the growth of IDO-expressing tumors by reducing kynurenine.
产品信息订购:
abs810180
Epacadostat (INCB024360)
5mg
650
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