Product name
CYP3A4 Polyclonal Antibody
Isotype
IgG
Form
Lyophilized or Liquid
Tested applications
WB,IF,ELISA,IHC
Species reactivity
Human,Mouse,Rat
Host Species
Rabbit
Purity
Affinity purification
Immunogen Information:
Immunogen
Recombinant protein of human CYP3A4
Calculated molecular weight
57kDa
Observed molecular weight
Refer to figures
Swiss Prot
P08684
Gene ID (NCBI)
1576
Alternative Names
CP33;CP34;CYP3A;CYP3A3;CYPIIIA3;CYPIIIA4;HLP;NF-25;P450C3;P450PCN1
Application Notes:
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
1:500 - 1:2000
IF
1:50 - 1:200
IHC
1:50 - 1:500
Background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
Storage:
Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
武汉华联科生物技术有限公司
联系商家时请提及chemicalbook,有助于交易顺利完成!