Recombinant Murine Lymphotactin/XCL1

Name

Recombinant Murine Lymphotactin/XCL1 (Recombinant Murine Lymphotactin/XCL1; rMuLymphotactin/XCL1)；Recombinant Mouse Lymphotactin/XCL1 ; 重组小鼠淋巴细胞趋化因子/XCL1

Synonyms

Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; Small-inducible cytokine C1; Xcl1; Lptn; Ltn; Scyc1

Purity

>97% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human XCR1 transfected murine BaF3 cells is less than 100ng/ml, corresponding to a specific activity of >1.0×10⁴IU/mg.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.

Endotoxin

Less than 0.1EU/μg of rMuLymphotactin/XCL1 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Chemokines

Background

Chemokine (C motif) ligand (XCL1), as known as lymphotactin, is the only known member of the C-chemokine family and signals through the receptor XCR1, formally known as GPR5. The expression of lymphotactin is abundant in some activated T cells such as activated CD8⁺ T cells and other class I MHC restricted T cells. It is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. XCL1 induces its chemotactic function by binding to a chemokine receptor called XCR1. Recombinant Murine XCL1 which is a single non-glycosylated polypeptide chains containing 93 amino acids and it shares approximately 60% and 82% amino acid sequence homology with the human and rat XCL1.

Amino Acid Sequence

VGTEVLEESS CVNLQTQRLP VQKIKTYIIW EGAMRAVIFV TKRGLKICAD PEAKWVKAAI KTVDGRASTR KNMAETVPTG AQRSTSTAIT LTG

产品编号

产品名称

包装

KL-6764-5μg

Recombinant Murine Lymphotactin/XCL1

5μg

KL-6764-20μg

Recombinant Murine Lymphotactin/XCL1

20μg

KL-6764-100μg

Recombinant Murine Lymphotactin/XCL1

100μg

KL-6764-1mg

Recombinant Murine Lymphotactin/XCL1

1mg

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说明书

1份